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Dehydroepiandrosterone sulfate (DHEAS)

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of dehydroepiandrosterone sulfate (DHEAS) in your blood, a hormone produced mainly by the adrenal glands. It reflects your body’s production of androgens, which are hormones involved in sex characteristics and overall health.

Quick summary

["DHEAS helps assess adrenal gland function and hormone balance, often linked to conditions like adrenal insufficiency or hormonal imbalances."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
49716-4
Short code
DHEA Sal-mCnc
Synonyms
DHEA Sal-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
135
Ref high
980
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is DHEAS Used For?

Doctors may order a DHEAS test to evaluate adrenal gland health, especially in cases of suspected adrenal disorders, hormonal imbalances, or conditions affecting sex hormone production. It can also be used in the diagnosis and monitoring of certain cancers, such as breast or prostate cancer, where hormone levels play a role.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. You may feel a small pinch when the needle is inserted, but the procedure is quick and usually not painful. The blood is then sent to a lab for analysis.

What Does a DHEAS Test Tell You?

While DHEAS levels can vary based on age, sex, and overall health, they are not typically used alone to diagnose conditions. Instead, they are often part of a broader evaluation. For example, low levels may suggest adrenal insufficiency or other hormonal issues, while very high levels could indicate conditions like Cushing’s syndrome or certain cancers.

What Are Common Causes of Abnormal Results?

Abnormal DHEAS levels can result from a variety of factors, including adrenal gland disorders, hormonal imbalances, certain cancers, or medications that affect hormone production. Always discuss your results with your healthcare provider, as they will consider your medical history and other test results to determine the best course of action.

Reference range

NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

DHEAS

Frequently asked questions

What does a DHEAS test measure?
A DHEAS test measures the concentration of dehydroepiandrosterone sulfate (DHEAS) in your blood. This hormone is produced by your adrenal glands and is involved in various bodily functions, including sex characteristics and metabolism.
How often should I get a DHEAS test?
The frequency of a DHEAS test depends on your medical needs and symptoms. Your healthcare provider will determine if and when to order this test based on your health history, symptoms, or other diagnostic requirements.
Can lifestyle changes affect DHEAS levels?
Yes, lifestyle factors such as diet, exercise, stress levels, and certain medications can influence hormone levels, including DHEAS. However, DHEAS is not typically affected by the same factors as other hormones like testosterone or estrogen, and its levels are generally more stable. Always discuss any lifestyle changes with your healthcare provider.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy