Skip to content

Dehydroepiandrosterone sulfate (DHEA-S) in serum/plasma

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of dehydroepiandrosterone sulfate (DHEA-S), a hormone produced primarily by the adrenal glands. It reflects your body’s natural production of hormones involved in metabolism, immune function, and stress response.

Quick summary

["DHEA-S levels can help assess adrenal health and hormone balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
76347-4
Short code
DHEA-S/Cortis SerPl-sRto
Synonyms
DHEA-S/Cortis SerPl-sRto
Category
hormone
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
135
Ref high
980
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order a DHEA-S test to evaluate adrenal gland function, especially if you have symptoms like fatigue, low energy, or hormonal imbalances. It can also be used in conditions such as adrenal insufficiency, Cushing’s syndrome, or to monitor hormone therapy.

What to Expect Before the Test

No special preparation is usually needed. You may fast before the test if instructed, but your provider will confirm. Bring any medications you’re taking, as some may affect results.

What Happens During the Test?

A blood sample will be drawn from a vein in your arm. This is a quick and typically painless procedure. The sample is sent to a lab for analysis.

What Do Results Mean?

Results are compared to general reference ranges, but individual results can vary based on age, sex, and health status. Low levels may suggest adrenal issues, while very high levels could indicate conditions like Cushing’s syndrome or tumors.

Reference range

NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

DHEA-S levels can provide insight into adrenal health and may help diagnose or monitor conditions affecting hormone production. It’s often used alongside other tests to assess overall endocrine function, especially in adults experiencing fatigue, weight changes, or hormonal symptoms.

Short name

DHEA-S

Frequently asked questions

What causes abnormal DHEA-S levels?
Abnormal DHEA-S levels can result from adrenal gland disorders (e.g., Addison’s disease or adrenal tumors), hormonal imbalances, or certain medications. Age and sex also influence reference ranges, so results should always be interpreted by a healthcare provider.
How long does it take to get results?
Test results are usually available within 1 to 3 business days, depending on your lab’s processing time. Your healthcare provider will discuss the findings with you during your follow-up visit.
Can lifestyle changes affect DHEA-S levels?
Yes, factors like stress, diet, and exercise can influence hormone levels. Maintaining a balanced diet, managing stress, and staying physically active may support healthy hormone production, but results should not be interpreted without professional guidance.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy