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Dehydroepiandrosterone sulfate (DHEAS) in serum/plasma

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of dehydroepiandrosterone sulfate (DHEAS), a hormone produced mainly by the adrenal glands, which helps regulate sex hormones and stress responses.

Quick summary

["DHEAS helps assess adrenal function and hormone balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
2193-1
Short code
DHEA SerPl-mCnc
Synonyms
DHEA SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
135
Ref high
980
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order a DHEAS test to evaluate adrenal gland health, check for conditions affecting hormone production, or monitor symptoms like fatigue, weight changes, or hormonal imbalances. It can also be part of a broader evaluation for conditions like adrenal insufficiency, Cushing’s syndrome, or congenital adrenal hyperplasia.

What to Expect Before the Test

No special preparation is typically needed, but you may be asked to fast for 8–12 hours before the blood draw if instructed. Wear comfortable clothing and plan to stay near the testing site for a short time while blood is collected.

What Happens During the Test?

A healthcare professional will insert a small needle into a vein in your arm to draw blood. You may feel a slight pinch, but the process usually takes just a few minutes. The blood sample is then sent to a lab for analysis.

What Are Possible Results?

Results are interpreted by your healthcare provider based on your medical history, symptoms, and other test results. Abnormal levels may indicate hormonal imbalances or adrenal issues, but they don’t provide a diagnosis alone.

Reference range

NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

DHEAS Level

Frequently asked questions

What does a low DHEAS level mean?
A low DHEAS level may suggest adrenal gland problems, such as adrenal insufficiency or certain genetic disorders. It could also be related to aging, chronic stress, or medications that affect hormone production. Your provider will consider your full medical picture to determine next steps.
What does a high DHEAS level mean?
High DHEAS levels might indicate overactive adrenal glands, conditions like Cushing’s syndrome, or rare genetic disorders. It can also be influenced by certain medications or liver disease. Your provider will review your symptoms and other test results to guide further evaluation.
Can diet or lifestyle affect DHEAS levels?
Yes, diet, stress, and certain medications can influence DHEAS levels. Avoiding alcohol and certain supplements (like licorice or herbal products) before testing may help ensure more accurate results. Your provider can offer personalized advice based on your situation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy