Dehydroepiandrosterone sulfate (DHEA-S) in serum/plasma

Why Is This Test Done?

Your healthcare provider may order a DHEA-S test to evaluate adrenal gland health, especially if you have symptoms like fatigue, low sex drive, or signs of hormonal imbalances. It can also be part of testing for conditions like Cushing’s syndrome, adrenal insufficiency, or certain cancers that produce hormones.

What Does a Low or High Result Mean?

Low DHEA-S levels might suggest adrenal gland problems, such as insufficient production of hormones or conditions like Addison’s disease. High levels could indicate overactivity of the adrenal glands or certain tumors. However, results alone don’t diagnose a condition—your provider will consider your symptoms and other test results.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The blood is then sent to a lab for testing using a high-performance liquid chromatography (HPLC) method, which separates and measures the DHEA-S concentration accurately.

What Should You Do Before the Test?

No special preparation is usually needed, but avoid smoking or drinking alcohol 24 hours before the test. If you’re on medications that affect hormone levels, let your provider know. Some conditions, like infections or stress, might temporarily alter results.