Skip to content

Dehydroepiandrosterone sulfate (DHEAS) in serum/plasma

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of dehydroepiandrosterone sulfate (DHEAS), a hormone produced by the adrenal glands that plays a role in sex hormone metabolism and overall health.

Quick summary

["DHEAS helps assess adrenal gland function and hormone balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
110436-3
Short code
DHEA-S Msmt Ur
Synonyms
DHEA-S Msmt Ur
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Ref low
135
Ref high
980
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Is DHEAS Used For?

DHEAS levels can be checked to evaluate adrenal gland health, especially in conditions like adrenal insufficiency or to monitor hormone-related disorders. It may also be used in research or clinical settings to assess sex hormone production in both men and women.

How Is the Test Performed?

A blood sample is drawn from a vein, typically in your arm. The blood is then processed to separate serum or plasma for testing. The test measures the concentration of DHEAS in the sample using an immunoassay method.

What Might Affect Your Results?

Several factors can influence DHEAS levels, including age, sex, medications (such as steroids), pregnancy, stress, and certain medical conditions. Hormonal therapies or supplements may also impact results.

When Might You Need This Test?

Your healthcare provider may order a DHEAS test if you have symptoms of hormonal imbalances, adrenal issues, or if you are being evaluated for conditions like adrenal insufficiency, Cushing’s syndrome, or other endocrine disorders.

Reference range

NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A

Specimen: urine

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

DHEAS

Frequently asked questions

Why do some people have their DHEAS tested?
DHEAS is often used as a marker for adrenal function and can help diagnose or monitor conditions affecting hormone production. Lower levels may indicate adrenal insufficiency, while higher levels could be associated with certain cancers or other metabolic disorders.
What do abnormal DHEAS results mean?
Abnormally low DHEAS levels may suggest adrenal gland problems or other hormonal imbalances. Abnormally high levels might require further investigation to rule out conditions like adrenal tumors or other metabolic issues. Always discuss results with your healthcare provider.
How often should I get this test?
The frequency of DHEAS testing depends on your medical condition and healthcare provider’s recommendations. Regular monitoring may be needed for chronic conditions like adrenal insufficiency or if you are undergoing hormone-related treatments.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy