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Dehydroepiandrosterone sulfate (DHEAS) in serum/plasma

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of dehydroepiandrosterone sulfate (DHEAS), a hormone produced by the adrenal glands that plays a role in sex hormone production and overall health.

Quick summary

["DHEAS helps assess adrenal gland function and may be checked for conditions affecting hormone balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
12593-0
Short code
DHEA sp5 p chal SerPl-mCnc
Synonyms
DHEA sp5 p chal SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
135
Ref high
980
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order a DHEAS test to evaluate adrenal gland health, diagnose conditions like adrenal insufficiency, or investigate symptoms related to hormone imbalances. It can also be part of a broader evaluation for certain cancers or genetic disorders.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if serum/plasma is collected. Avoid alcohol for 24 hours before testing. Let your provider know about any medications or supplements you’re taking.

How the Test Is Performed

A blood sample is drawn from a vein in your arm by a healthcare professional. The sample is then sent to a lab for analysis using a high-performance liquid chromatography (hplc) method to measure DHEAS levels accurately.

What the Results Mean

DHEAS levels can vary based on age, sex, and health conditions. Your results will be compared to reference ranges provided by your lab and discussed with your provider to determine if further action is needed.

Reference range

NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

DHEAS

Frequently asked questions

What causes DHEAS levels to be abnormal?
Abnormal DHEAS levels may be linked to adrenal gland disorders, certain cancers (like ovarian or testicular cancer), or hormonal imbalances. Your provider may also check for conditions like polycystic ovary syndrome (PCOS) or other metabolic disorders.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab’s processing time. Your provider will contact you once they’re ready to discuss the findings.
Can lifestyle changes affect DHEAS levels?
Yes, factors like stress, diet, and certain medications (e.g., steroids) can influence DHEAS levels. Avoiding alcohol and managing stress may help provide more accurate results, but your provider will interpret results in the context of your overall health.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy