Skip to content

Dehydroepiandrosterone sulfate (DHEAS) in serum/plasma

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of dehydroepiandrosterone sulfate (DHEAS), a hormone produced primarily in the adrenal glands. It reflects your body’s production of this steroid precursor, which can influence sex hormone balance.

Quick summary

["DHEAS helps assess adrenal function and hormone levels, often used in conditions related to hormone imbalances or adrenal disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
12594-8
Short code
DHEA sp6 p chal SerPl-mCnc
Synonyms
DHEA sp6 p chal SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
135
Ref high
980
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is DHEAS Used For?

DHEAS is commonly measured to evaluate adrenal gland health, especially in cases of suspected adrenal insufficiency, Cushing’s syndrome, or hyperandrogenism. It may also be checked in conditions affecting sex hormone production, such as premature ovarian insufficiency or androgen-related disorders. Some doctors use it to monitor treatment responses in hormone-related conditions.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate serum or plasma for testing. The lab uses a specialized immunoassay method to detect and quantify DHEAS levels.

What Does a DHEAS Test Tell You?

While DHEAS levels can indicate adrenal function, they are not a standalone diagnostic tool. They may be used alongside other tests (like cortisol or ACTH) to support a diagnosis of adrenal disorders. Results can vary based on age, sex, and overall health, so they should be interpreted by a healthcare provider in context.

Common Reasons for Testing

Your doctor might order a DHEAS test if you have symptoms like fatigue, weight changes, or hormonal imbalances. It may also be part of a broader evaluation for conditions like adrenal tumors, congenital adrenal hyperplasia, or hormonal deficiencies.

Reference range

NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

DHEAS

Frequently asked questions

Why might my DHEAS levels be checked?
Your doctor may recommend this test if you have symptoms or risk factors for adrenal or hormonal disorders, such as unexplained fatigue, high blood pressure, or irregular menstrual cycles in women. It can also help assess adrenal function in certain genetic conditions or after treatment for hormone-related illnesses.
What do my DHEAS results mean?
DHEAS results alone don’t provide a diagnosis—they’re part of a larger picture. A low level might suggest adrenal insufficiency, while very high levels could indicate adrenal tumors or other hormonal imbalances. Always discuss your results with your healthcare provider, as they’ll consider your medical history and other test results.
How often should I get a DHEAS test?
DHEAS testing is typically not a routine screening test. Your doctor will order it only if needed for diagnosis, monitoring, or evaluating a specific condition. Follow their guidance on timing and frequency.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy