Dehydroepiandrosterone sulfate (DHEA-S) in serum/plasma
This test measures the level of dehydroepiandrosterone sulfate (DHEA-S), a hormone produced by the adrenal glands that plays a role in energy levels, immune function, and sex hormone production.
["DHEA-S helps assess adrenal gland health and hormone balance."]
Key facts at a glance
- LOINC
- 16732-0
- Short code
- DHEA sp7 p chal SerPl-mCnc
- Synonyms
- DHEA sp7 p chal SerPl-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 135
- Ref high
- 980
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82626
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Is DHEA-S Used For?
Doctors may order a DHEA-S test to evaluate adrenal function, especially in conditions like adrenal insufficiency, Cushing’s syndrome, or to monitor hormone levels in people with chronic illnesses or during aging. It can also be part of a broader evaluation for hormonal imbalances or metabolic health.
How Is the Test Performed?
A blood sample is drawn from a vein in your arm. The blood is processed to separate serum or plasma, where the DHEA-S hormone is measured using a specialized laboratory technique.
What Does a Low or High DHEA-S Level Mean?
Low levels may indicate adrenal gland issues, stress, or certain medical conditions. High levels could suggest adrenal tumors or other hormonal disorders, though this is less common. Your doctor will interpret results in the context of your overall health and symptoms.
Common Reasons for Testing
Your doctor might recommend this test if you have symptoms like fatigue, weight changes, muscle loss, or if you’re being treated for conditions like Addison’s disease, Cushing’s syndrome, or metabolic disorders.
Reference range
NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
DHEA-S
Frequently asked questions
Why might my doctor want to check my DHEA-S level?
What should I expect before or after the test?
Can lifestyle changes affect DHEA-S levels?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy