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Dehydroepiandrosterone sulfate (DHEAS) in serum/plasma

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of dehydroepiandrosterone sulfate (DHEAS), a hormone produced by the adrenal glands that plays a role in sex hormone production and overall health.

Quick summary

["DHEAS helps assess adrenal gland function and hormone balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
59840-9
Short code
DHEA sp8 p chal SerPl-mCnc
Synonyms
DHEA sp8 p chal SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
135
Ref high
980
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Doctors may order a DHEAS test to evaluate adrenal gland health, especially in conditions like adrenal insufficiency, congenital adrenal hyperplasia, or to monitor hormone levels in both men and women. It can also be used in the evaluation of certain cancers or metabolic disorders.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate serum or plasma, which is sent to a lab for analysis using a chemiluminescent immunoassay (CLIA) method.

What Do the Results Mean?

Results are not typically provided in absolute numbers but are compared to reference ranges that may vary by lab. High or low levels can indicate underlying health concerns that require further medical evaluation.

Common Conditions Monitored

DHEAS levels can be checked in cases of suspected adrenal disorders, hormonal imbalances, or during the evaluation of conditions like Cushing’s syndrome, polycystic ovary syndrome (PCOS), or certain cancers.

Reference range

NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

DHEAS

Frequently asked questions

What does a DHEAS test measure?
A DHEAS test measures the concentration of dehydroepiandrosterone sulfate (DHEAS), a hormone produced by your adrenal glands that contributes to sex hormone production and overall metabolism.
Can DHEAS levels change with age?
Yes, DHEAS levels can naturally decline with age, particularly in adults. This is why reference ranges may differ between age groups and why your doctor may consider your age when interpreting results.
Is fasting required for this test?
No fasting is required for a DHEAS test. You can eat and drink normally before the blood draw.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy