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Dehydroepiandrosterone sulfate (DHEA-S) in serum/plasma

Published: August 9, 2026Updated: August 17, 2026

This test measures the sulfate form of dehydroepiandrosterone (DHEA), a hormone produced primarily in the adrenal glands. It reflects your body’s natural production of this hormone, which plays a role in energy levels, stress response, and overall health.

Quick summary

["DHEA-S helps assess adrenal function and may be useful in evaluating conditions linked to hormone balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
16721-3
Short code
DHEA-S Sal-mCnc
Synonyms
DHEA-S Sal-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
135
Ref high
980
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is DHEA-S Used For?

Doctors may order a DHEA-S test to evaluate adrenal gland health, especially in cases of suspected adrenal insufficiency, Cushing’s syndrome, or other hormonal imbalances. It can also be part of a broader evaluation for conditions affecting stress response or energy metabolism.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The blood is then processed to separate serum or plasma, which is sent to a lab for analysis using a specialized immunoassay method to measure DHEA-S levels.

What Might Influence Results?

Several factors can affect DHEA-S levels, including age (levels tend to decline with age), certain medications (such as steroids), stress, and underlying health conditions like adrenal disorders. Recent physical activity, diet, or illness can also temporarily impact results.

When Might You Need This Test?

You might need a DHEA-S test if you have symptoms like fatigue, low energy, or unexplained weight changes. It may also be ordered as part of a workup for conditions like Addison’s disease, premature ovarian insufficiency, or other hormonal disorders.

Reference range

NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

DHEA-S

Frequently asked questions

Why might my DHEA-S test be done at different times of the day?
DHEA-S levels can fluctuate slightly throughout the day, but they are generally stable enough that a single test is usually sufficient. If your doctor suspects a specific condition, they may recommend testing at a particular time or under specific conditions, such as fasting.
Can diet or supplements affect my DHEA-S test results?
Yes, certain foods, supplements, or medications—like high-dose vitamin C or some herbal supplements—can influence hormone levels. If you’re taking supplements or have dietary restrictions, let your healthcare provider know before testing.
What should I do if my DHEA-S test results are outside the expected range?
If your results are abnormal, your doctor will review them in the context of your overall health, symptoms, and medical history. They may recommend further testing or adjustments to treatment plans based on the findings.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy