Skip to content

Dehydroepiandrosterone sulfate (DHEA-S) in serum/plasma

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of dehydroepiandrosterone sulfate (DHEA-S), a hormone produced by the adrenal glands that plays a role in energy levels, stress response, and sex hormone production.

Quick summary

["DHEA-S levels can help assess adrenal gland function and overall hormone balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
107494-7
Short code
DHEA-S SerPl LC/MS/MS-mCnc
Synonyms
DHEA-S SerPl LC/MS/MS-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
135
Ref high
980
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
lc-ms-ms
CPT
82626
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is DHEA-S Used For?

DHEA-S is often measured to evaluate adrenal gland health, especially in conditions like adrenal insufficiency or hyperandrogenism. It may also be checked in cases of chronic fatigue, stress, or hormonal imbalances. Some doctors use it to monitor treatment responses in hormone-related disorders.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate serum or plasma, which is sent to a lab for analysis using a high-performance liquid chromatography (hplc) method to measure DHEA-S levels.

What Does a DHEA-S Test Tell You?

Lower-than-expected DHEA-S levels may suggest adrenal gland problems, such as insufficient production of hormones. Higher-than-expected levels could indicate conditions like Cushing’s syndrome or certain tumors. However, results should be interpreted by your healthcare provider in the context of your overall health.

When Might You Need This Test?

Your doctor may recommend a DHEA-S test if you have symptoms like fatigue, low energy, or unexplained weight changes. It may also be part of a broader evaluation for hormonal disorders, adrenal issues, or chronic stress responses.

Reference range

NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

DHEA-S

Frequently asked questions

Why might my DHEA-S levels be checked regularly?
Regular monitoring may be recommended if you have a history of adrenal gland disorders, hormonal imbalances, or conditions affecting stress responses. Your doctor will consider your symptoms, medical history, and other test results to guide this decision.
What can affect DHEA-S test results?
Factors like diet, stress levels, medications (including steroids), and certain medical conditions can influence DHEA-S levels. Avoiding alcohol and certain supplements before the test may help ensure accurate results. Always follow your doctor’s instructions for preparation.
Is a DHEA-S test painful?
The blood draw itself may cause mild discomfort, but most people tolerate it well. A healthcare professional will apply a small amount of numbing cream if needed. Afterward, you may experience a slight bruise or soreness at the site, but this usually fades quickly.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy