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Dehydroepiandrosterone sulfate (DHEA-S) in serum/plasma

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of dehydroepiandrosterone sulfate (DHEA-S), a hormone produced primarily by the adrenal glands. It reflects your body’s natural production of this steroid hormone.

Quick summary

["DHEA-S helps assess adrenal gland function and may be useful in evaluating conditions related to hormone balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
2191-5
Short code
DHEA-S SerPl-mCnc
Synonyms
DHEA-S SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
135
Ref high
980
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order a DHEA-S test to check for adrenal gland issues, such as adrenal insufficiency or hyperfunction. It can also be used in the evaluation of conditions like Cushing’s syndrome, congenital adrenal hyperplasia, or to monitor hormone-related disorders. Sometimes, it’s part of a broader evaluation for hormonal imbalances or metabolic health.

What Does a Low or High Level Mean?

Low levels of DHEA-S may indicate problems with your adrenal glands, such as insufficient production of hormones. High levels could suggest overactivity of the adrenal glands or certain genetic conditions. However, individual results depend on your overall health and medical history.

How Is This Test Performed?

A blood sample is taken from a vein in your arm. The sample is sent to a lab where it is analyzed using a specialized immunoassay method to measure DHEA-S levels.

What Should You Do Before the Test?

No special preparation is usually needed for this test. However, if you are taking medications that affect hormones, such as steroids, inform your healthcare provider before the test.

Reference range

NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

DHEA-S

Frequently asked questions

What are the normal ranges for DHEA-S?
There is no single standard reference range for DHEA-S because levels can vary based on age, sex, and overall health. Your results will be interpreted in the context of your medical history and symptoms.
Does DHEA-S change with age?
Yes, DHEA-S levels naturally decline with age. Men and women typically have different reference ranges, and levels can also fluctuate due to stress, diet, or other health conditions.
Can lifestyle factors affect DHEA-S levels?
Yes, lifestyle choices such as diet, exercise, stress levels, and smoking can influence DHEA-S levels. Maintaining a balanced lifestyle may help support healthy hormone production.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy