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Dehydroepiandrosterone sulfate (DHEA-S) in serum/plasma

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of dehydroepiandrosterone sulfate (DHEA-S), a hormone produced primarily by the adrenal glands. It reflects your body’s natural production of this hormone, which plays a role in energy levels, immune function, and sex hormone balance.

Quick summary

["DHEA-S levels can help assess adrenal gland health and hormone balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
59983-7
Short code
DHEA-S sp1 p chal SerPl-mCnc
Synonyms
DHEA-S sp1 p chal SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
135
Ref high
980
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order a DHEA-S test to evaluate adrenal function, especially in conditions like adrenal insufficiency, Cushing’s syndrome, or to monitor hormone-related disorders. It can also be used in research or clinical studies involving hormone metabolism.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before the test if your lab requires it. Bring any medications you’re currently taking to your appointment.

How the Test Works

A blood sample is drawn from a vein in your arm. The sample is processed to separate serum or plasma, which is then analyzed using an immunoassay method to measure DHEA-S levels.

What the Results Mean

Results are typically reported in micrograms per deciliter (µg/dL). While reference ranges vary by lab, lower-than-expected levels may suggest adrenal gland issues, while higher-than-expected levels could indicate conditions like polycystic ovary syndrome (PCOS) or certain cancers.

Reference range

NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: DHEA-S Levels and Health

Short name

DHEA-S

Frequently asked questions

What could cause abnormal DHEA-S levels?
Abnormally low DHEA-S levels may be linked to adrenal insufficiency, aging, certain medications (e.g., steroids), or autoimmune diseases. High levels could be associated with conditions like PCOS, obesity, or tumors affecting hormone production.
How often should I get this test?
Your provider will determine the frequency based on your medical history, symptoms, and treatment needs. Routine screening for DHEA-S is not typically recommended unless you have specific health concerns.
Can lifestyle changes affect DHEA-S levels?
Yes, factors like diet, exercise, stress, and sleep can influence hormone levels, including DHEA-S. Maintaining a balanced lifestyle may support healthy hormone production, but results depend on individual health and medical context.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy