Dehydroepiandrosterone sulfate (DHEA-S) in serum/plasma
This test measures the sulfate form of dehydroepiandrosterone (DHEA), a hormone produced primarily by the adrenal glands. It reflects your body’s natural production of this steroid precursor, which can influence energy levels, stress response, and hormone balance.
["DHEA-S helps assess adrenal gland function and may indicate hormonal health."]
Key facts at a glance
- LOINC
- 16727-0
- Short code
- DHEA-S sp6 p chal SerPl-mCnc
- Synonyms
- DHEA-S sp6 p chal SerPl-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 135
- Ref high
- 980
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82626
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your healthcare provider may order a DHEA-S test to evaluate adrenal gland health, especially if you have symptoms like fatigue, low energy, or signs of hormonal imbalances. It can also be used in conditions such as adrenal insufficiency, Cushing’s syndrome, or to monitor treatment responses in certain hormonal disorders.
What to Expect Before the Test
No special preparation is typically needed, but you may be asked to fast for 8–12 hours before the blood draw if instructed by your provider. Wear comfortable clothing and plan to rest afterward, as you might feel lightheaded.
What Happens During the Test?
A healthcare professional will collect a blood sample from a vein in your arm. You may feel a slight pinch, but the process usually takes just a few minutes. The blood will be sent to a lab for analysis.
What Are Possible Results?
Results are not provided in absolute numeric ranges here, as they vary by lab and individual factors. Your provider will interpret the results in the context of your symptoms, medical history, and other tests.
Reference range
NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
DHEA-S levels can provide insights into adrenal function and may be useful in diagnosing or monitoring conditions affecting hormone production. Low levels might suggest adrenal insufficiency, while elevated levels could indicate conditions like Cushing’s syndrome or certain tumors. Always discuss results with your healthcare provider.
Short name
DHEA-S
Frequently asked questions
What does a low DHEA-S level mean?
How long does it take to get results?
Can lifestyle changes affect DHEA-S levels?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy