Dehydroepiandrosterone sulfate (DHEAS) in serum/plasma
This test measures the level of dehydroepiandrosterone sulfate (DHEAS), a hormone produced mainly by the adrenal glands. It reflects your body’s production of this hormone, which plays a role in sex hormone balance and overall health.
["DHEAS helps assess adrenal function and hormone balance."]
Key facts at a glance
- LOINC
- 16729-6
- Short code
- DHEA-S sp8 p chal SerPl-mCnc
- Synonyms
- DHEA-S sp8 p chal SerPl-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 135
- Ref high
- 980
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82626
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your healthcare provider may order a DHEAS test to evaluate adrenal gland function, especially if you have symptoms like fatigue, weight changes, or hormonal imbalances. It can also be used in conditions like adrenal insufficiency, Cushing’s syndrome, or to monitor treatment for hormone-related disorders.
What Does a Low or High Level Mean?
Low levels of DHEAS might indicate adrenal gland problems, such as adrenal insufficiency or autoimmune conditions affecting the adrenal glands. High levels could suggest overactivity of the adrenal glands or certain genetic conditions.
Common Conditions Monitored
DHEAS is often checked in people with suspected adrenal disorders, hormonal imbalances, or those undergoing treatment for conditions like Cushing’s disease or androgen deficiency.
Sample Collection and Preparation
A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate serum or plasma for testing. You may be asked to fast or avoid certain medications before the test, depending on your provider’s instructions.
Reference range
NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: DHEAS plays a key role in hormone regulation, particularly in converting to other sex hormones like testosterone and estrogen. Abnormal levels can signal underlying health issues, such as adrenal dysfunction, hormonal imbalances, or metabolic disorders, guiding further medical evaluation.
Short name
DHEAS
Frequently asked questions
What does a DHEAS test measure?
How long does it take to get results?
Can I eat or drink before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy