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Dehydroepiandrosterone sulfate (DHEAS)

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of dehydroepiandrosterone sulfate (DHEA-S) in your blood, a hormone produced by your adrenal glands that plays a role in sex hormone production and overall health.

Quick summary

["DHEA-S levels can help assess adrenal function and may be relevant in conditions affecting hormone balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
34280-8
Short code
DHEA-S Ur-sCnc
Synonyms
DHEA-S Ur-sCnc
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Ref low
135
Ref high
980
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Is DHEA-S Used For?

Doctors may order a DHEA-S test to evaluate adrenal gland health, especially in cases of suspected adrenal insufficiency, hormonal imbalances, or conditions like Cushing’s syndrome or congenital adrenal hyperplasia. It can also be part of routine testing for certain chronic illnesses or during pregnancy.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The sample is sent to a lab where it is analyzed to measure the concentration of DHEA-S. No special preparation is usually needed, but fasting may be advised depending on the clinic’s protocol.

What Might Affect Results?

Factors like stress, certain medications (such as corticosteroids), recent illness, or hormonal treatments can influence DHEA-S levels. It’s important to inform your healthcare provider about all medications or supplements you’re taking.

Interpreting Your Results

While reference ranges can vary by lab, DHEA-S levels are often discussed in relation to broader health trends rather than absolute cutoffs. Your doctor will consider your medical history and symptoms when interpreting results.

Reference range

NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A

Specimen: urine

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

DHEA-S

Frequently asked questions

Why was this test ordered?
Your doctor may have ordered this test to check for adrenal gland issues, hormonal disorders, or to monitor conditions like adrenal fatigue, autoimmune disorders, or metabolic health. It can also be part of a broader evaluation for symptoms such as fatigue, weight changes, or hormonal imbalances.
What do abnormal results mean?
Low DHEA-S levels may suggest adrenal gland problems or other hormonal deficiencies, while very high levels could indicate conditions like polycystic ovary syndrome (in women) or certain tumors. However, results alone don’t diagnose a condition—your doctor will review them with your full medical picture.
Do DHEA-S levels change with age?
Yes, DHEA-S levels naturally decline with age, often starting in middle adulthood. This decline can be part of normal aging, but it may also be influenced by lifestyle factors like diet, exercise, and stress management. Your doctor may consider age when discussing results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy