Skip to content

Dehydroepiandrosterone sulfate (DHEAS)

Published: August 9, 2026Updated: August 17, 2026

This test measures the level of dehydroepiandrosterone sulfate (DHEA-S) in your blood. DHEA-S is a hormone produced by your adrenal glands and plays a role in sex hormone production and overall health.

Quick summary

["DHEA-S levels can help assess adrenal gland function and hormone balance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
2194-9
Short code
DHEA Ur Ql
Synonyms
DHEA Ur Ql
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Ref low
135
Ref high
980
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Might You Need This Test?

Your healthcare provider may order a DHEA-S test to evaluate adrenal gland health, especially if you have symptoms like fatigue, low libido, or hormonal imbalances. It can also be used in diagnosing conditions like adrenal insufficiency or monitoring treatment for hormone-related disorders.

What to Expect During the Test

A blood sample is typically taken from a vein in your arm. You may feel a slight pinch when the needle is inserted, but the procedure usually takes less than five minutes. No special preparation is usually needed, but follow any instructions your provider gives you.

Common Reasons for Testing

DHEA-S levels can be checked if you have symptoms of adrenal dysfunction, such as unexplained fatigue, weight changes, or hormonal issues. It may also be part of a broader evaluation for conditions like Cushing’s syndrome, adrenal tumors, or hormonal disorders.

How the Test Works

The test measures the concentration of DHEA-S in your blood. Your sample is sent to a lab where it is analyzed using a specialized immunoassay method to detect and quantify the hormone.

Reference range

NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A

Specimen: urine

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

DHEA-S

Frequently asked questions

What Does a Low DHEA-S Level Indicate?
Low DHEA-S levels may suggest adrenal gland problems, such as adrenal insufficiency or chronic stress. It can also be associated with aging, certain medications, or underlying health conditions affecting hormone production.
What Does a High DHEA-S Level Indicate?
High DHEA-S levels can sometimes be seen in conditions like adrenal tumors or polycystic ovary syndrome (PCOS) in women. However, elevated levels alone may not always indicate a specific condition and should be interpreted with other clinical findings.
How Often Should I Get This Test?
The frequency of DHEA-S testing depends on your medical history, symptoms, and reasons for the test. Your healthcare provider will determine the best schedule based on your individual needs, such as monitoring treatment or assessing ongoing health concerns.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy