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Dihydroxyphenylacetic acid (DHPAA) in urine

Published: August 9, 2026Updated: August 16, 2026

This test measures a chemical produced when your body breaks down certain neurotransmitters, often linked to metabolic or neurological health.

Quick summary

["DHPAA helps assess metabolic function and may be part of broader screening for conditions like Parkinson’s disease or other dopamine-related disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
111895-9
Short code
Diam PD Endscpy
Synonyms
Diam PD Endscpy
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
endoscopy
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

Dihydroxyphenylacetic acid (DHPAA) is a metabolite of dopamine, a neurotransmitter involved in movement, mood, and cognitive function. Your body naturally produces it as dopamine is broken down. This test detects its presence in urine, which can reflect how efficiently your body processes dopamine and other related chemicals.

Why Might Your Doctor Order This Test?

Doctors may request this test if they suspect conditions affecting dopamine metabolism, such as Parkinson’s disease, certain neurological disorders, or metabolic issues. It can also be part of broader evaluations for symptoms like movement problems, mood changes, or other neurological symptoms.

Sample Collection and Preparation

A clean-catch urine sample is typically collected in the morning. You’ll urinate into a sterile container, and the sample is sent to the lab for analysis. Follow your healthcare provider’s instructions carefully to ensure accurate results.

What to Expect During the Test

This is a non-invasive test that doesn’t require special preparation beyond standard urine collection. Results are usually available within a few days, depending on lab processing times.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated levels of DHPAA in urine may suggest imbalances in dopamine metabolism, potentially linked to neurological disorders or metabolic conditions. Lower-than-expected levels could indicate other metabolic or hormonal factors. Always discuss results with your healthcare provider, as they’ll interpret them in the context of your overall health and symptoms.

Short name

DHPAA Urine

Frequently asked questions

What causes abnormal DHPAA levels?
Abnormal DHPAA levels can result from conditions affecting dopamine production, such as Parkinson’s disease, certain genetic disorders, or metabolic issues. Medications, diet, and other health factors may also influence results. Your doctor will consider all possible causes based on your medical history and symptoms.
How often should I get this test?
The frequency of this test depends on your healthcare provider’s recommendations. Some patients may need it periodically to monitor conditions like Parkinson’s disease, while others may only get it once as part of a diagnostic evaluation. Follow your doctor’s advice.
Can lifestyle changes affect DHPAA levels?
Yes, lifestyle factors such as diet, exercise, and certain medications can influence dopamine metabolism and, consequently, DHPAA levels. Avoiding certain foods or supplements, staying active, and managing stress may help support normal metabolic function. Always consult your doctor before making significant changes.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy