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Cholinesterase (Serum or Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity of an enzyme called cholinesterase, which helps break down certain chemicals in your blood. It can be used to assess liver function or exposure to certain medications or toxins.

Quick summary

["Cholinesterase helps your body process medications and toxins; low levels may signal liver issues or drug exposure."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73420-2
Short code
Dicyclomine ind plt IgM SerPl Ql FC
Synonyms
Dicyclomine ind plt IgM SerPl Ql FC
Category
hematology
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have symptoms like fatigue, muscle weakness, or liver problems. It’s also used to monitor people exposed to certain pesticides, solvents, or medications that can affect cholinesterase levels.

What to Expect Before the Test

No special preparation is usually needed. You may have a small needle inserted into your arm or vein to draw blood. If you’re taking medications that could affect cholinesterase, let your provider know.

What the Results Mean

Results are compared to a general reference range for healthy adults. Very low levels might indicate liver disease, exposure to toxins, or certain medications. Very high levels could suggest genetic conditions or specific drug interactions.

Common Causes of Abnormal Results

Low cholinesterase levels can be linked to liver disease, exposure to organophosphate pesticides, or certain medications like some antibiotics or anesthetics. High levels may occur with genetic variations or specific medications.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Cholinesterase testing is particularly important for people with liver conditions, those exposed to toxins, or those taking medications that rely on this enzyme for metabolism. It helps identify potential health risks early and guides treatment decisions.

Short name

Cholinesterase Level

Frequently asked questions

Could this test detect liver disease?
Yes, while not the *primary* test for liver disease, low cholinesterase levels can sometimes signal liver dysfunction or damage. It’s often used alongside other tests for a full picture.
Does this test require fasting?
No, fasting is not required for this blood test. However, let your provider know if you’re taking medications that might affect results.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on your lab’s processing time.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy