Protein Electrophoresis on Cerebrospinal Fluid (CSF)

Why This Test Is Done

Your doctor may order this test if they suspect conditions affecting the central nervous system, such as multiple sclerosis, meningitis, or brain tumors. It can also help diagnose or monitor certain genetic disorders or metabolic conditions that alter protein levels in CSF.

What to Expect Before the Test

You’ll likely have a lumbar puncture (spinal tap) to collect the CSF. This procedure involves lying on your side and having a needle inserted into your lower back to draw fluid. You may feel a slight pressure or discomfort, but it’s usually brief. No special preparation is needed beyond staying hydrated.

What the Results Mean

The test separates proteins into bands (e.g., albumin, globulins) and compares them to normal ranges. Abnormal patterns—such as high levels of immunoglobulin bands—may suggest conditions like multiple sclerosis (demyelinating disease) or infections like meningitis. Your doctor will interpret results in context of your symptoms and medical history.

Common Conditions Monitored

This test is critical for diagnosing or managing conditions like multiple sclerosis (where abnormal protein bands may appear), Lyme disease, infections (e.g., tuberculosis), or certain cancers (e.g., lymphoma). It may also help assess metabolic or genetic disorders affecting protein synthesis.