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Digoxin Level (Serum)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of digoxin, a medication used to treat heart conditions like irregular heartbeat or heart failure, in your blood.

Quick summary

["Digoxin levels help ensure you’re taking the right dose for your condition without risking toxicity."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
4222-6
Short code
Digoxin Dose
Synonyms
Digoxin Dose
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.5
Ref high
2
Critical range
— – 4 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Digoxin is a medication that helps regulate your heart’s rhythm. Too much can cause side effects like nausea, vision changes, or irregular heartbeat, while too little may not work effectively. This test checks how much digoxin is in your blood to guide your treatment.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for a few hours before the test if it’s drawn early in the morning. Bring any medications you’re currently taking, as they may affect results.

How the Test Is Done

A healthcare provider will draw blood from a vein in your arm. You may feel a small pinch, but it usually takes only a few minutes. The blood sample is sent to a lab for analysis.

What the Results Mean

Results help your doctor adjust your digoxin dose if needed. They’re used to monitor whether your medication is working safely or if you need changes to avoid side effects.

Reference range

Therapeutic: 0.5-2.0 ng/mLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Digoxin Blood Test

Frequently asked questions

How often should I get this test?
Your doctor will determine how often you need this test based on your condition, medication regimen, and how well your body is responding to digoxin. It’s often checked periodically, especially if you’ve had changes in your symptoms or medication.
What are the typical side effects of digoxin?
Common side effects of digoxin include nausea, vomiting, dizziness, or blurred vision. If you experience these symptoms or notice changes in your heartbeat, contact your healthcare provider immediately.
Can I still take digoxin if I’m pregnant?
Digoxin is generally not recommended during pregnancy unless absolutely necessary, as it can pose risks to both mother and baby. Always discuss your pregnancy with your doctor before continuing or stopping any medications.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy