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Digoxin (Serum) Concentration

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of digoxin, a medication used to treat certain heart conditions, in your blood.

Quick summary

["Digoxin levels help doctors monitor your treatment for heart rhythm or heart failure."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
83094-3
Short code
Digoxin SerPl IA-sCnc
Synonyms
Digoxin SerPl IA-sCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
17
Critical range
— – 4 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you’re taking digoxin to check if your dose is working properly. It’s also used to diagnose or manage conditions like heart failure or irregular heartbeats (arrhythmias). Regular monitoring helps prevent side effects like low heart rate or nausea.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. The process usually takes a few minutes. If you’re on digoxin, your doctor may adjust your dose based on this result.

What the Results Mean

Results show your current digoxin level in the blood. Too much can cause side effects, while too little may mean your heart isn’t responding well to the medication. Your doctor will interpret the result in relation to your symptoms and medical history.

Possible Side Effects or Risks

The blood draw itself is generally safe but may cause mild discomfort or bruising. Rarely, there could be allergic reactions to the blood collection process. If you’re pregnant, breastfeeding, or have certain health conditions, let your doctor know before the test.

Reference range

NCBI: NSE 0-17 ng/mLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Digoxin Level

Frequently asked questions

How often should I get this test?
Your doctor will determine the frequency based on your treatment plan, symptoms, and how well you’re responding to digoxin. Some patients need testing weekly or monthly, while others may only need it occasionally.
What if my results are too high or too low?
If your level is too high, your doctor may reduce your dose or temporarily stop it to avoid dangerous side effects. If it’s too low, they may increase your dose. Always follow your doctor’s instructions.
Does diet or exercise affect this test?
Digoxin is absorbed through your digestive system, so eating or drinking certain foods (like licorice) or taking supplements (like St. John’s wort) could affect your level. Avoid these until your doctor confirms it’s safe.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy