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Genetic Mutation Analysis for DLD (Diverticular Disease-Associated Gene) via Whole Blood DNA

Published: August 9, 2026Updated: August 16, 2026

This test checks for mutations in the *DLD* gene, which may be linked to an increased risk of certain gastrointestinal conditions, including diverticular disease. It involves analyzing DNA from your blood.

Quick summary

["Helps assess genetic predisposition to digestive health risks."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
77750-8
Short code
DLD gene Mut Anl Bld/T
Synonyms
DLD gene Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

The *DLD* gene codes for a protein involved in cellular processes that can be disrupted by mutations. Certain variants may raise the risk of diverticular disease (pockets in the colon) or other gastrointestinal disorders. This test specifically looks for inherited mutations in this gene using DNA extracted from your blood sample.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of diverticular disease, colorectal cancer, or other gastrointestinal conditions. It could also be part of a broader genetic evaluation if you have symptoms like abdominal pain, bloating, or unexplained digestive issues.

Sample Collection and Process

A small blood sample is drawn from your arm. The DNA is then isolated from the blood cells and analyzed for mutations in the *DLD* gene using advanced genetic testing techniques.

What to Expect Before the Test

No special preparation is needed. You may eat and drink normally on the day of the test. If you’re on blood-thinning medications, let your provider know before the draw.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

DLD Gene Mutation Screen (Whole Blood)

Frequently asked questions

Will this test show if I already have diverticular disease?
No. This test looks for inherited genetic mutations in the *DLD* gene, not current symptoms or existing disease. If you have signs of diverticular disease, other tests (like imaging or endoscopy) would be needed to confirm diagnosis.
Can I get this test if I don’t have a family history?
Yes, but it’s less common. Some people may choose this test for preventive screening, especially if they have risk factors like a sedentary lifestyle, obesity, or smoking. Always discuss with your provider whether it’s appropriate for you.
What if my test results are positive for a *DLD* mutation?
If mutations are detected, your provider will explain next steps, which may include genetic counseling, closer monitoring of digestive health, or recommendations for diet, exercise, or other preventive measures tailored to your needs.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy