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Total Ceruloplasmin (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of ceruloplasmin, a protein in your blood that helps transport copper and acts as an antioxidant.

Quick summary

["Ceruloplasmin helps identify copper metabolism issues or Wilson’s disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
61257-2
Short code
D microceras IgE/IgE total %
Synonyms
D microceras IgE/IgE total %
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms like fatigue, abdominal pain, or liver problems, or if you have a family history of copper storage disorders. It may also be used to monitor treatment for conditions like Wilson’s disease.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm to draw blood. If you’re on blood thinners, let your doctor know before the test.

What the Results Mean

Results are compared to a general reference range for healthy adults. Abnormally low levels may suggest copper storage disorders or liver disease, while very high levels could indicate inflammation or certain infections.

Common Conditions Linked to Ceruloplasmin

Low ceruloplasmin is often seen in Wilson’s disease (a copper toxicity disorder), liver disease, or chronic kidney disease. High levels may be linked to infections, inflammation, or certain medications.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Ceruloplasmin plays a key role in copper metabolism and antioxidant defense. Low levels may signal underlying disorders requiring further evaluation, such as genetic copper disorders or liver dysfunction.

Short name

Ceruloplasmin Level

Frequently asked questions

What causes ceruloplasmin levels to be low?
Low ceruloplasmin can result from liver disease, Wilson’s disease (a genetic disorder affecting copper), chronic kidney disease, or certain medications. If you have unexplained fatigue or liver symptoms, discuss this with your doctor.
What does it mean if my ceruloplasmin is high?
Elevated ceruloplasmin may indicate inflammation (e.g., infections, autoimmune conditions), pregnancy, or certain medications. If your levels are consistently high, your doctor may investigate underlying causes like infections or liver issues.
Can ceruloplasmin levels change with diet?
Dietary copper intake may slightly influence ceruloplasmin, but its primary role is metabolic rather than dietary. If your doctor suspects dietary factors, they may recommend further testing or adjustments.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy