DNA Fragmentation Index (measured via a qualitative assay on whole blood)

What This Test Measures

DNA fragmentation refers to the breakdown of DNA strands into smaller pieces. Normally, this happens naturally during cell death, but elevated levels can signal excessive cell stress, such as during trauma, infection, or certain diseases. This test detects these fragments qualitatively, meaning it provides a yes/no or present/absent result rather than a precise measurement.

Why It Might Be Ordered

Your healthcare provider may order this test to investigate symptoms like fatigue, unexplained bruising, or signs of systemic inflammation. It can also be part of a broader evaluation for conditions affecting cell health, such as autoimmune diseases or severe infections.

Sample Collection and Preparation

A small blood sample is drawn from your arm. The test is performed on whole blood, and results are typically reported as qualitative (positive or negative for DNA fragmentation). No special preparation is needed, but fasting may not be required unless specified by your provider.

What the Results Mean

A positive result (detecting fragmented DNA) suggests your cells may be experiencing stress or damage. This could be due to acute events like trauma, severe illness, or chronic conditions. A negative result means no significant fragmentation was detected in this sample.