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DNA Fragmentation Index (Cell-Free Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of fragmented DNA in your blood, which can help assess cellular stress or apoptosis (programmed cell death).

Quick summary

["Helps evaluate conditions linked to DNA damage or cell death in your body."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
34976-1
Short code
DNA Index 2 Spec FC-aCnc
Synonyms
DNA Index 2 Spec FC-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test detects small, fragmented pieces of DNA that are released into the bloodstream when cells undergo stress, injury, or programmed death. This can occur naturally or due to underlying health conditions.

Why Might Your Doctor Order This Test?

Your doctor may recommend this test to investigate conditions such as cancer, autoimmune diseases, or other conditions where cell death or DNA damage is suspected.

Sample Collection and Preparation

A blood sample is collected, typically from a vein in your arm. The plasma portion is separated and analyzed for DNA fragments using advanced laboratory techniques.

Common Uses and Conditions

This test is often used in research or specialized clinical settings to monitor conditions like cancer progression, response to treatment, or to assess cellular health in chronic diseases.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical significance involves understanding whether elevated levels of fragmented DNA correlate with disease activity, treatment response, or other biological processes. It may be particularly useful in oncology for detecting early signs of tumor activity or monitoring treatment efficacy.

Short name

DNA Fragmentation Index

Frequently asked questions

Why do some people need this test?
This test is primarily used in research or specialized clinical studies, not as a routine diagnostic tool for most patients. It may be ordered if you have a suspected condition involving significant cell death or DNA damage, such as certain cancers or autoimmune disorders.
How is the test performed?
The test involves drawing blood and analyzing the plasma for DNA fragments. Advanced laboratory methods detect these fragments to generate the DNA fragmentation index.
What are the possible results?
Results are qualitative or semi-quantitative and may indicate elevated or normal levels of DNA fragmentation. Your doctor will interpret the results in the context of your medical history and symptoms.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy