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DNA Fragmentation Index (or Apoptosis Marker) with Fluorescence-Based Quantification

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of fragmented DNA, often linked to cell death (apoptosis). It may be used to assess conditions affecting cell health or response to treatments.

Quick summary

["Helps evaluate cell death processes in blood or other tissues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
34972-0
Short code
DNA Index 3 Spec FC-aCnc
Synonyms
DNA Index 3 Spec FC-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

DNA fragmentation is a hallmark of programmed cell death (apoptosis). When cells undergo apoptosis, their DNA breaks into small fragments, which this test detects. The index quantifies this fragmentation to assess the extent of cell death in a sample.

Why It Might Be Ordered

Your healthcare provider may order this test to monitor conditions involving abnormal cell death, such as certain cancers, autoimmune diseases, or after treatments like chemotherapy. It can also help evaluate blood disorders or organ damage.

Sample and Testing Process

This test typically uses whole blood or plasma. Fluorescence-based methods detect and quantify DNA fragments. Results are often expressed as an index or ratio to compare against normal levels.

Common Uses and Conditions

While not a routine screening test, it may be used in research or specialized clinical settings to study cell death mechanisms. It’s not a standard diagnostic tool for most conditions but can provide insights in specific contexts.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

DNA Fragmentation Index

Frequently asked questions

How long will it take to get my results?
Results are usually available within 1–3 business days, depending on lab processing times. Follow-up with your provider will help interpret the meaning of your specific result.
What does a high or low result mean?
A high DNA fragmentation index may suggest increased cell death, which could be seen in conditions like cancer, autoimmune diseases, or severe infections. A low index may indicate normal or reduced cell death. Your provider will discuss these findings in relation to your health.
Can this test be done at home?
No, this test requires a lab sample collected by a healthcare professional. Specialized equipment and expertise are needed for accurate results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy