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Serum or Plasma Creatinine Concentration (Quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood or plasma. It helps assess kidney function by checking how well your kidneys filter blood.

Quick summary

["Kidney health check: creatinine levels help detect early kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
100963-8
Short code
DNV 1+2+3+4 nsP1 IgG SerPl IA-aCnc
Synonyms
DNV 1+2+3+4 nsP1 IgG SerPl IA-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

Creatinine is a byproduct of muscle breakdown and is normally filtered out by your kidneys. Elevated levels may suggest impaired kidney function, while lower levels could indicate overhydration or other conditions. This test is often used alongside other measures like blood urea nitrogen (BUN) to evaluate kidney performance.

Why Is This Test Done?

Doctors order creatinine tests to monitor kidney health, especially in people with risk factors like diabetes, high blood pressure, or a family history of kidney disease. It may also be used before surgeries, during pregnancy, or to check for kidney issues after an injury or illness.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The sample is sent to a lab where it is analyzed to measure creatinine concentration using an automated method, often enzymatic or spectrophotometric. No special preparation is needed, but fasting may be advised in some cases.

What Are Common Results?

Results are typically reported in milligrams per deciliter (mg/dL) or micromoles per liter (µmol/L). While exact reference ranges vary by lab, higher than expected levels may indicate kidney problems, while very low levels may need further investigation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Kidney Function and Disease Detection

Short name

Creatinine Level

Frequently asked questions

What causes elevated creatinine levels?
Elevated creatinine levels can result from reduced kidney function (e.g., chronic kidney disease), dehydration, severe muscle damage, or conditions that slow blood flow to the kidneys. It’s important to discuss symptoms like swelling, fatigue, or changes in urine output with your doctor.
What causes low creatinine levels?
Low creatinine levels may occur in people with very little muscle mass, overhydration, or certain liver or heart conditions. If your levels are consistently low, your doctor may investigate further to rule out underlying issues.
Can diet affect creatinine levels?
Yes, diet can influence creatinine levels. High-protein diets may temporarily increase creatinine, while dehydration can raise it. Your doctor may recommend dietary adjustments or timing your test around meals if needed.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy