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Serum or Plasma Digoxin Concentration (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of digoxin, a medication used to treat certain heart conditions, in your blood.

Quick summary

["Digoxin levels help ensure your medication dose is safe and effective."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
7286-8
Short code
Dog Epith BasoBnd Ab Qn
Synonyms
Dog Epith BasoBnd Ab Qn
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
lhr
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you’re taking digoxin to manage heart rhythm or fluid buildup. It helps check if your dose is working properly or if you’re developing too much of the drug in your system, which could cause side effects like nausea, irregular heartbeat, or confusion.

How the Test Works

A blood sample is taken from a vein, usually in your arm. The sample is sent to a lab where it’s analyzed using a sensitive test to measure the exact amount of digoxin present.

What to Expect Before the Test

No special preparation is needed, but let your provider know if you’re taking other medications or have recent illnesses. Avoid eating or drinking for 2 hours before the test if instructed.

What the Results Mean

Results are compared to a standard range to determine if your digoxin level is too high or too low. High levels may require dose adjustments or temporary stopping of the medication.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Digoxin is a narrow therapeutic window drug, meaning small changes in levels can significantly affect heart function. High levels can cause toxicity with symptoms like vomiting, dizziness, or heart palpitations, while low levels may mean the medication isn’t working as intended. Regular monitoring is crucial for patients on long-term digoxin therapy.

Short name

Digoxin Level

Frequently asked questions

How often do I need this test?
Your provider will determine the frequency based on your medication regimen, heart condition, and how well you’re responding to treatment. Typically, it’s done every few weeks or months if you’re on a stable dose.
What happens if my digoxin level is too high?
If your level is elevated, your provider may reduce your dose, temporarily stop the medication, or prescribe a medication to help lower the level. They’ll also monitor you closely for symptoms of toxicity.
Can I eat or drink before this test?
Generally, you should avoid eating or drinking for 2 hours before the test unless your provider gives specific instructions. This helps ensure the most accurate reading of your digoxin level.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy