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Plasma Dopamine Metabolite (Dopamine 3-Methoxy-4-Hydroxyphenylglycol, or MHPG) Screening in Pregnancy

Published: August 9, 2026Updated: August 17, 2026

This test measures a breakdown product of dopamine, a chemical messenger in your brain, to help assess potential stress or hormonal influences during pregnancy.

Quick summary

["This screening may help identify possible stress-related changes in your body during pregnancy."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
80864-2
Short code
DOP for pregnancy
Synonyms
DOP for pregnancy
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Critical range
0.5 N/A – —
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
us-doppler
CPT
86592
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like high blood pressure, anxiety, or other signs of stress-related conditions that could affect your pregnancy. It may also be part of a broader evaluation for certain pregnancy-related concerns.

What to Expect Before the Test

You’ll typically provide a blood sample drawn from your vein. No special preparation is needed, but let your provider know about any medications or supplements you’re taking, as they may affect results.

What the Test Measures

The test detects MHPG, a metabolite of dopamine, which is broken down in your body. Elevated levels may suggest increased stress hormones, though this can vary based on individual health and pregnancy stages.

How Results Are Interpreted

Results are not always straightforward and may require clinical correlation. Your provider will discuss findings in the context of your symptoms, medical history, and overall pregnancy health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Dopamine metabolite screening

Frequently asked questions

What does a high or low MHPG level mean during pregnancy?
High levels may indicate increased stress or hormonal activity, but they don’t always point to a specific health issue. Low levels could suggest reduced dopamine metabolism, though this is less common and may need further investigation with your provider.
Does this test help diagnose pregnancy complications like preeclampsia?
No, this test alone is not used to diagnose pregnancy complications. It may be part of a broader evaluation but isn’t a standalone indicator of conditions like preeclampsia or gestational diabetes.
Can I fast before this blood test?
No fasting is required for this test, as it involves a simple blood draw. However, always follow your provider’s instructions for any specific preparations.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy