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Serum/plasma concentration of digoxin (Digitalis glycoside)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of digoxin, a medication used to treat certain heart conditions, in your blood. It helps ensure your dose is safe and effective.

Quick summary

["Digoxin levels help balance heart rhythm and prevent dangerous side effects."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
73404-6
Short code
Doxazosin ind plt IgG SerPl Ql FC
Synonyms
Doxazosin ind plt IgG SerPl Ql FC
Category
hematology
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you’re taking digoxin to treat conditions like heart failure, atrial fibrillation, or irregular heartbeats. It’s also used to monitor your response to the medication or check for toxicity.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm or vein to draw blood. If you’re on a strict diet or taking certain supplements, let your provider know beforehand.

What the Results Mean

Results help determine if your digoxin levels are within a safe range. Too much can cause nausea, vision changes, or irregular heartbeats, while too little may mean the medication isn’t working properly.

Common Causes of Abnormal Results

Factors like kidney disease, dehydration, or other medications (e.g., certain antibiotics or diuretics) can affect digoxin levels. Your provider will consider these when interpreting results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Digoxin levels are critical for patients with heart conditions. High levels can lead to dangerous arrhythmias or heart failure, while low levels may indicate insufficient treatment. Regular monitoring helps prevent complications and adjusts medication as needed.

Short name

Digoxin Level

Frequently asked questions

How often should I get this test?
Your provider will schedule follow-up tests based on your treatment plan, medication dose, and overall health. Typically, tests are done every few weeks or months to check for stability.
What are the typical symptoms if my digoxin level is too high?
Symptoms of high digoxin levels may include nausea, vomiting, confusion, vision changes (like seeing halos around lights), weakness, or irregular heartbeat. Seek medical attention if you experience these symptoms.
Does diet or food affect digoxin levels?
Dietary changes alone rarely affect digoxin levels, but certain foods (like licorice) or supplements (e.g., St. John’s wort) may interact with the medication. Always discuss your diet and supplements with your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy