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D-Pyridinoline (DPYD) in Urine, Quantitative

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of D-pyridinoline, a breakdown product of collagen found in urine, which helps assess bone metabolism and potential bone loss or turnover.

Quick summary

["This test may help evaluate bone health and detect conditions affecting bone breakdown."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
104296-9
Short code
DPYD gene.c.1905+1G>A Bld/T Ql
Synonyms
DPYD gene.c.1905+1G>A Bld/T Ql
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or risk factors for conditions like osteoporosis, hyperparathyroidism, or other bone-related disorders. It could also be used to monitor treatment progress for conditions affecting bone metabolism.

What to Expect Before the Test

No special preparation is typically needed. You may be asked to collect a urine sample in the morning, often on an empty stomach. Follow your provider’s instructions carefully to ensure accurate results.

What the Results Mean

Higher than expected levels may suggest increased bone breakdown, while lower levels might indicate reduced bone turnover. Your results will be interpreted in relation to your overall health and medical history.

Common Conditions Monitored

This test is often used to monitor conditions such as osteoporosis, Paget’s disease, or other metabolic bone diseases. It can also help assess the effectiveness of treatments targeting bone health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Bone Metabolism and Turnover

Short name

Urine D-Pyridinoline

Frequently asked questions

How often will I need this test?
The frequency depends on your medical condition and treatment plan. Your healthcare provider will determine how often this test should be repeated based on your specific situation.
What if my results are outside the normal range?
If your results are outside the normal range, your provider will discuss them with you and may recommend further tests, adjustments to your treatment, or additional evaluations to understand the cause and guide management.
Can I take any medications before this test?
Some medications, particularly those affecting bone metabolism or urine production, may influence results. Always inform your healthcare provider about all medications, supplements, or treatments you are taking before the test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy