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D-dimer, quantitative (plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of D-dimer, a protein fragment produced when blood clots dissolve. It helps assess whether you’re at risk of clot-related complications.

Quick summary

["D-dimer helps diagnose blood clots or rule them out safely."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63410-5
Short code
dsDNA Ab CSF IA-aCnc
Synonyms
dsDNA Ab CSF IA-aCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order a D-dimer test to investigate symptoms like unexplained shortness of breath, chest pain, leg swelling, or unexplained bruising. It’s also used to evaluate conditions like deep vein thrombosis (blood clots in the legs), pulmonary embolism (clots in the lungs), or other clotting disorders.

How the Test Works

A small blood sample is taken from a vein. The test detects D-dimer, a breakdown product of clotting proteins, using a sensitive immunoassay method. Higher levels suggest recent clot formation or dissolution.

What to Expect Before the Test

No special preparation is needed, but inform your provider about any medications (e.g., blood thinners) or recent surgeries that could affect results.

What the Results Mean

Low or normal levels usually mean no active clotting is present. Elevated levels may indicate recent clots, inflammation, or other conditions. Your provider will interpret results in context with your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

D-Dimer

Frequently asked questions

What causes elevated D-dimer levels?
Elevated D-dimer can occur with blood clots (thrombosis), severe infections, pregnancy, or conditions causing inflammation. It may also rise after surgery or trauma.
Can D-dimer levels be affected by medications?
Yes, certain blood thinners (e.g., warfarin, heparin) or anti-inflammatory drugs may influence D-dimer levels, so let your provider know if you’re taking them.
Is there any risk or discomfort with this test?
Minimal discomfort may occur from the needle stick, but most people tolerate it well. Rarely, there could be bruising or slight bleeding at the site.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy