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D-dimer (serum/plasma, quantitative immunoassay)

Published: August 9, 2026Updated: August 16, 2026

This test measures the D-dimer protein, a breakdown product formed when blood clots dissolve. It helps assess whether abnormal clotting or clot-dissolving processes may be occurring in your body.

Quick summary

["D-dimer helps diagnose blood clots or bleeding disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
53148-3
Short code
dsDNA Ab Fld Ql
Synonyms
dsDNA Ab Fld Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is D-Dimer Used For?

D-dimer is primarily used to evaluate conditions involving blood clots, such as deep vein thrombosis (DVT) or pulmonary embolism. It can also support the diagnosis of other clotting disorders or help rule out bleeding complications in certain situations.

How Is the Test Performed?

A small blood sample is drawn from a vein, usually in your arm. The blood is processed to separate the serum or plasma, where the D-dimer levels are measured using an immunoassay method. This test is typically done quickly and can be part of a routine blood workup.

When Might You Need This Test?

Your healthcare provider may recommend a D-dimer test if you have symptoms like swelling, pain in your legs (possible DVT), chest pain or shortness of breath (possible pulmonary embolism), or if you have a history of clotting disorders. It may also be used in certain surgical or medical settings to monitor bleeding risks.

What Do My Results Mean?

High levels of D-dimer may suggest recent clot formation or clot-dissolving activity, while very low levels are usually normal. However, results alone cannot diagnose a clot or bleeding disorder without clinical correlation. Your doctor will interpret the results in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

D-Dimer

Frequently asked questions

Why might my doctor order a D-dimer test if I don’t have symptoms?
Your doctor may order a D-dimer test for preventive screening, especially if you have risk factors for blood clots (e.g., recent surgery, long periods of immobility, or certain medical conditions). It can also be part of a broader evaluation for conditions like stroke or heart attack in some cases.
Can D-dimer levels change over time, and how often should I get retested?
Yes, D-dimer levels can fluctuate depending on your health status, medications, or recent medical events. If your doctor recommends follow-up testing, they will determine the appropriate timing based on your specific situation. Avoiding strenuous activity or certain medications (like blood thinners) for a few days before testing can sometimes improve accuracy.
Is there anything I should do to prepare for this test?
No special preparation is usually needed, but inform your doctor about any medications you’re taking, especially blood thinners like warfarin or heparin, as they can affect results. If you have a history of clotting disorders, your doctor may provide additional guidance tailored to your needs.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy