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DNA Adducts in Plasma (Measured by High-Performance Liquid Chromatography)

Published: August 9, 2026Updated: August 16, 2026

This test measures chemical changes to your DNA caused by exposure to certain substances, including environmental toxins or medications.

Quick summary

["Helps assess potential DNA damage from exposures that may increase cancer risk or affect cell health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
109610-6
Short code
dsDNA Ab Msmt Plr
Synonyms
dsDNA Ab Msmt Plr
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

What Does This Test Measure?

DNA adducts are small molecules that attach to your DNA, often from environmental pollutants, certain medications, or smoking. This test detects these adducts in your plasma to evaluate DNA damage at a molecular level.

Why Might You Need This Test?

Your healthcare provider may order this test if you have a history of exposure to known carcinogens, are at higher risk for certain cancers, or if you’re undergoing treatment that could affect DNA integrity.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The plasma portion is then analyzed using high-performance liquid chromatography to identify and quantify DNA adducts.

What Are the Possible Results?

Results are reported as a concentration of DNA adducts, though exact reference ranges vary by lab and may not be standardized. Higher levels may indicate increased exposure or risk.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

DNA Adducts (Plasma)

Frequently asked questions

What does a high or low result mean?
A high result may suggest increased exposure to harmful substances, which could raise concerns about cancer risk or other health effects. A low result doesn’t necessarily mean no exposure occurred, but it may indicate lower levels of DNA damage.
How often should I get this test?
The frequency depends on your medical needs, exposure history, and healthcare provider’s recommendations. Follow-up may be needed if you have ongoing exposure to known carcinogens or specific risk factors.
Can lifestyle changes affect this test?
Yes, reducing exposure to known toxins (e.g., smoking, certain chemicals) or improving diet and hydration may lower DNA adduct levels over time. Always discuss lifestyle changes with your provider before or after testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy