Dual-stranded DNA Antibody Screening (Serum)
This test measures antibodies that may react with DNA found in your blood. It helps identify certain autoimmune conditions or infections.
["This screening may help diagnose conditions affecting your immune system or detect possible infections involving DNA-related substances."]
Key facts at a glance
- LOINC
- 111462-8
- Short code
- dsDNA Ab Msmt Ser
- Synonyms
- dsDNA Ab Msmt Ser
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Does This Test Measure?
The test detects the presence of antibodies that bind to double-stranded DNA. These antibodies can be produced by your immune system in response to certain autoimmune diseases or as part of an immune reaction to infections.
Why Might You Need This Test?
Your healthcare provider may order this test if you have symptoms or risk factors for autoimmune diseases like lupus, where the immune system mistakenly attacks healthy cells, or if you have been exposed to conditions involving DNA-related substances.
How Is the Test Performed?
A blood sample is taken from a vein in your arm. The serum portion of your blood is then analyzed to check for specific antibodies against DNA.
What Are Possible Results?
Results are qualitative (positive or negative) and indicate whether antibodies were detected. A positive result suggests a higher likelihood of an autoimmune condition or an immune response to DNA-related substances, but further testing is needed for diagnosis.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: This test is primarily used as a screening tool. Positive results may prompt additional testing, such as confirmatory assays or further evaluation of symptoms, to determine the underlying cause. It is not a definitive diagnostic test alone and should be interpreted by a healthcare professional in the context of your medical history and symptoms.
Short name
DNA Antibody Screen
Frequently asked questions
What does a positive result mean?
What if I have a negative result?
How often should I get this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy