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Serum DNA (Mass Concentration) – Antibody Screening

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies in your blood that may react with DNA, a component of cells. It helps identify potential autoimmune or inflammatory conditions.

Quick summary

["This test helps detect unusual immune responses to DNA, which may signal underlying health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
32677-7
Short code
dsDNA Ab Ser IA-aCnc
Synonyms
dsDNA Ab Ser IA-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test looks for the presence of antibodies that bind to DNA in your serum. These antibodies can be part of a broader immune response, sometimes linked to autoimmune diseases or other systemic conditions.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms like joint pain, unexplained fatigue, or signs of an autoimmune disorder. It can also be part of a broader evaluation for conditions affecting the immune system.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The serum (liquid part of blood) is then analyzed to detect specific antibodies against DNA using a sensitive laboratory method.

What Are Possible Results?

Results are qualitative (positive or negative) and indicate whether antibodies were found. A positive result suggests an abnormal immune response, but further testing may be needed to determine the cause.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

DNA Antibody Screen (Serum)

Frequently asked questions

What does a positive result mean?
A positive result means your blood contains antibodies that react with DNA. This could indicate an autoimmune condition or an inflammatory process, but it doesn’t definitively diagnose a specific disease. Your doctor will discuss next steps, such as additional tests or monitoring.
How often should I get this test?
The frequency depends on your symptoms, medical history, and treatment plan. Your healthcare provider will determine how often to repeat this test based on your individual needs.
Can lifestyle changes affect this test?
While some autoimmune conditions may be influenced by diet, stress, or other lifestyle factors, this specific test measures antibodies in your blood and isn’t directly affected by daily habits. Your doctor will consider all factors when interpreting results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy