DNA Antibody Screening by Line Probe Assay (Serum/Plasma)
This test detects specific antibodies against nuclear DNA, often used to evaluate autoimmune conditions that target the body’s own genetic material.
["Helps identify potential autoimmune responses linked to conditions like lupus or other connective tissue disorders."]
Key facts at a glance
- LOINC
- 81716-3
- Short code
- dsDNA Ab Ser Ql Line blot
- Synonyms
- dsDNA Ab Ser Ql Line blot
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- line-blot
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your doctor may order this test if you have symptoms like joint pain, fatigue, or unexplained rashes that could suggest an autoimmune disease affecting DNA-related processes. It may also be used as part of a broader screening for conditions like systemic lupus erythematosus (SLE) or Sjögren’s syndrome.
How the Test Works
A small sample of your blood (serum or plasma) is analyzed using a line probe assay. This method detects the presence of antibodies that bind to specific DNA sequences, helping identify whether your immune system is reacting to nuclear DNA.
Sample Collection and Preparation
Blood is drawn from a vein in your arm, and the serum or plasma is separated and sent to the lab for testing. No special preparation is needed, but fasting may not be required unless specified by your doctor.
What to Expect After Testing
Results are typically available within 3–5 business days. If antibodies are found, further testing may be needed to confirm a diagnosis or guide treatment.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Positive results for DNA antibodies can indicate autoimmune conditions where the immune system mistakenly targets nuclear DNA, potentially affecting organs like the kidneys, skin, or joints. While not all positive results mean a definitive diagnosis, they may prompt additional testing or monitoring to assess symptoms and guide treatment decisions.
Short name
DNA Antibody Screen (Line Blot)
Frequently asked questions
What does a positive result mean?
Can lifestyle changes help if I have DNA antibodies?
How often will I need retesting?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy