D-Serine in Plasma (24-Hour Urine Collection)

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or conditions linked to abnormal D-serine metabolism, such as certain neurological disorders, metabolic diseases, or as part of a broader diagnostic evaluation for unexplained neurological symptoms. It could also be used in research or specialized clinical studies.

What to Expect Before the Test

You’ll need to collect all urine for a full 24-hour period, typically starting after you wake up the first morning. Store the urine in a refrigerator or at room temperature, and bring the entire sample to your lab. Follow your provider’s instructions carefully to ensure accurate results.

What Happens During the Test

No blood draw is required for this test. Instead, you’ll provide a complete 24-hour urine sample, which is then analyzed in a lab to measure D-serine levels. The lab will process the sample using a specialized method (likely immunoassay or chromatography) to detect the amino acid.

What the Results Mean

Results are typically reported as a concentration value (e.g., micrograms per liter or milligrams per day) rather than a simple pass/fail. Abnormal levels may indicate metabolic or neurological conditions, but interpretation depends on clinical context and other test results. Your provider will discuss these findings with you.