Dual-Specific Antibody Titration for DNA Binding (e.g., Anti-dsDNA Antibody Titration)
This test measures the level of antibodies that target double-stranded DNA, often used to help diagnose conditions like lupus (systemic lupus erythematosus).
["This test helps assess autoimmune activity linked to certain connective tissue disorders."]
Key facts at a glance
- LOINC
- 63223-2
- Short code
- dsDNA Ab Titr Plr IF
- Synonyms
- dsDNA Ab Titr Plr IF
- Category
- chemistry
- Sample
- fluid
- Container
- Sterile tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- if
- Specimen volume
- 2-5 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h
- Hemolysis max
- 300
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your doctor may order this test if you have symptoms suggestive of autoimmune diseases, such as joint pain, fatigue, rash, or unexplained kidney problems. It can also be part of monitoring for conditions like lupus or other connective tissue disorders.
What to Expect Before the Test
No special preparation is typically needed. You may be asked to fast for 8–12 hours before the blood draw if your lab requires it, but this is not always the case. Bring your lab results and any current medications to your appointment.
How the Test Works
A small amount of blood is drawn from a vein in your arm. The sample is then tested in a lab to detect the presence and concentration of antibodies that bind to double-stranded DNA.
What the Results Mean
Results are interpreted by your healthcare provider based on your clinical symptoms, medical history, and other test results. Elevated levels may suggest an autoimmune condition, but further evaluation is needed to confirm a diagnosis.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
High antibody levels to double-stranded DNA are strongly associated with systemic lupus erythematosus and other autoimmune diseases affecting the kidneys, joints, and skin. While this test is not definitive, it is a key part of diagnosing or monitoring these conditions. Your doctor will use these results alongside other findings to guide treatment decisions.
Short name
Anti-double-stranded DNA Antibody Test
Frequently asked questions
What does a positive result mean?
Can I get this test at home?
How long does it take to get results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy