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D-dimer, plasma mass concentration measured by mass spectrometry

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of D-dimer, a protein fragment produced when certain blood clots break down. It helps assess whether you may have a blood clot or clotting disorder.

Quick summary

["D-dimer helps diagnose blood clots or bleeding risks by detecting clot breakdown products."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63535-9
Short code
dsDNA IgG CSF-aCnc
Synonyms
dsDNA IgG CSF-aCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Is D-dimer Used For?

D-dimer is primarily used to evaluate conditions involving abnormal clot formation, such as deep vein thrombosis (DVT) or pulmonary embolism. It can also help rule out certain bleeding disorders or guide decisions about anticoagulant therapy.

How Is the Test Performed?

Blood is drawn from a vein, usually in your arm. The sample is processed to separate plasma, which is then analyzed using mass spectrometry to measure D-dimer levels.

Why Might You Need This Test?

Your healthcare provider may order a D-dimer test if you have symptoms of blood clots (e.g., leg swelling, shortness of breath) or if you’re at risk due to conditions like heart disease, cancer, or recent surgery.

What Do Results Mean?

High D-dimer levels suggest recent clot activity, while very low levels may indicate no active clotting. Results alone aren’t diagnostic—they’re often used alongside other tests or clinical findings.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: D-dimer is a key marker for diagnosing venous thromboembolism (clots in veins or lungs). Elevated levels support the need for further testing or treatment, while normal levels may reduce unnecessary investigations in some cases.

Short name

D-dimer

Frequently asked questions

What causes D-dimer to be elevated?
D-dimer levels rise when blood clots form or break down, often due to conditions like DVT, pulmonary embolism, pregnancy, surgery, or severe infections. It can also be slightly elevated in older adults or those with heart disease.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times. Your provider will discuss them with you during your follow-up visit.
Can lifestyle changes affect D-dimer levels?
While lifestyle factors like exercise or diet may influence overall clotting risk, they don’t typically alter D-dimer levels directly. Your provider will consider your overall health when interpreting results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy