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D-dimer mass concentration in plasma (quantitative)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of D-dimer, a protein fragment produced when certain blood clots break down. It helps assess the risk of blood clots or conditions like deep vein thrombosis or pulmonary embolism.

Quick summary

["D-dimer helps diagnose or monitor blood clot risks."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63385-9
Short code
dsDNA IgG Fld FC-aCnc
Synonyms
dsDNA IgG Fld FC-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why is this test done?

Your doctor may order a D-dimer test to check for signs of blood clots, especially if you have symptoms like swelling, pain in your legs, or shortness of breath. It can also be used to evaluate conditions like deep vein thrombosis (DVT) or pulmonary embolism (PE).

What does a high or low result mean?

A high D-dimer level often suggests recent blood clotting activity, which may indicate conditions like DVT or PE. However, a low level does not always mean there are no clots, as other factors can affect the test. Your doctor will use the result along with other tests and symptoms to make a diagnosis.

How is the test performed?

A blood sample is taken from a vein in your arm. The blood is then processed to measure the D-dimer levels in your plasma. This test is usually done in a lab using a sensitive method to detect even small amounts of D-dimer.

What should I expect before the test?

There are no special preparations needed for this test. You can eat and drink normally on the day of the test. If you are on blood thinners, let your doctor know before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

D-dimer

Frequently asked questions

What are the possible results and what do they mean?
A positive or elevated D-dimer result strongly suggests the presence of blood clots, prompting further testing or treatment. A negative result means there is no detectable D-dimer, which can help rule out blood clots in many cases. However, false negatives can occur, so your doctor may still recommend additional tests if symptoms persist.
How often should I get this test?
The frequency of this test depends on your medical condition and treatment plan. Your doctor will determine how often you need it based on your symptoms, medical history, and other factors.
Can lifestyle changes affect my D-dimer levels?
D-dimer levels are influenced by recent blood clotting events, not typically by lifestyle changes like diet or exercise. However, if you have underlying conditions such as heart disease or cancer, these may affect your results. Always discuss any concerns with your healthcare provider.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy