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D-dimer, Serum/Plasma Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of D-dimer, a protein fragment produced when blood clots break down. It helps assess the risk of blood clots or conditions like deep vein thrombosis or pulmonary embolism.

Quick summary

["D-dimer helps diagnose or rule out blood clot risks."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63226-5
Short code
dsDNA IgG Fld IA-aCnc
Synonyms
dsDNA IgG Fld IA-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is D-Dimer Used For?

Doctors use the D-dimer test primarily to evaluate whether you have a condition involving abnormal blood clotting. It can help determine if you’re at risk for deep vein thrombosis (DVT) or pulmonary embolism (PE), which are serious blood clot problems in the legs or lungs. This test is often used alongside other tests to guide decisions about further medical care.

How Is the D-Dimer Test Performed?

A blood sample is taken from a vein in your arm. The blood is then processed to measure D-dimer levels. The test is usually done in a lab and can be completed quickly. You may need to fast for a few hours before the test, but this depends on your doctor’s instructions.

What Might Affect Your Results?

Several factors can influence D-dimer levels, including recent blood clotting events, pregnancy, certain medications (like anticoagulants), infections, or inflammatory conditions. If you have any of these factors, it’s important to discuss them with your healthcare provider before or after the test.

When Might You Need This Test?

Your doctor may recommend a D-dimer test if you have symptoms like swelling, pain in your legs, shortness of breath, or chest pain that could suggest a blood clot. It may also be used as part of a screening process for people at higher risk of clots, such as those with a history of DVT or PE.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

D-Dimer Test

Frequently asked questions

Why do I need this test if I don’t have symptoms?
Even without symptoms, your doctor might order this test if you have risk factors for blood clots, such as being immobile for long periods, having a family history of clotting disorders, or taking certain medications that increase clot risk. Early detection can help prevent serious complications.
What are the possible results and what do they mean?
Results can vary based on your health and medical history. Very low levels may suggest no active clotting activity, while elevated levels could indicate recent clot formation or other conditions affecting blood clotting. Your doctor will interpret the result in the context of your overall health and symptoms.
Can I eat or drink before this test?
Most likely, you’ll need to fast for a few hours before the test, but always follow your doctor’s specific instructions. Avoiding alcohol and strenuous activity for 24 hours before the test may also help ensure accurate results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy