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DNA Immunoglobulin G (IgG) Free Light Chains (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the free light chains of Immunoglobulin G (IgG), a type of antibody protein in your blood. These light chains can sometimes appear in excess, which may indicate conditions like multiple myeloma or other immune system disorders.

Quick summary

["Measuring free light chains helps doctors diagnose and monitor certain blood disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
110951-1
Short code
dsDNA IgG Msmt Fld
Synonyms
dsDNA IgG Msmt Fld
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like unexplained fatigue, frequent infections, bone pain, or if they suspect conditions such as multiple myeloma, lymphoma, or other immune-related diseases. It may also be used to monitor treatment progress or check for abnormal protein levels in your blood.

What to Expect Before the Test

No special preparation is needed for this test. You may have a small needle inserted into a vein in your arm to draw blood. It usually takes a few minutes, and you may feel a brief pinch. If you have a hard time with needles, let your provider know so they can help make it more comfortable.

What the Test Results Mean

The test measures the amount of free light chains in your serum. High levels may suggest conditions like multiple myeloma or other disorders affecting antibody production. Your results will be compared to a reference range provided by your healthcare provider, who will interpret them in the context of your overall health and symptoms.

Common Conditions Monitored

This test is often used to diagnose or monitor conditions such as multiple myeloma, where abnormal plasma cells produce too many light chains. It can also help detect other conditions like Waldenström macroglobulinemia or other lymphoproliferative disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

IgG Free Light Chains

Frequently asked questions

What Does an Abnormal Result Mean?
If your results show higher than expected levels of free light chains, your doctor may investigate further to determine the underlying cause. This could include additional tests, imaging, or a biopsy. Low levels alone are less commonly significant but may warrant discussion with your healthcare provider.
Can Diet or Lifestyle Affect This Test?
Diet or lifestyle factors typically do not directly affect free light chain levels in this test. However, if you are on certain medications (like chemotherapy or steroids), your doctor may already be aware of this and adjust monitoring accordingly.
How Often Will I Need This Test?
The frequency of this test depends on your medical condition and treatment plan. Your doctor will determine how often you need follow-up tests, which could range from monthly to yearly or more, depending on your situation.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy