Skip to content

D-dimer (Plasma) with High-Sensitivity Measurement

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein fragment called D-dimer, which forms when blood clots break down. It helps assess the risk of blood clots in your blood vessels.

Quick summary

["A high D-dimer level may signal an increased risk of clot formation, while a low level suggests fewer clots are present."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63386-7
Short code
dsDNA IgG Plr FC-aCnc
Synonyms
dsDNA IgG Plr FC-aCnc
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
flow-cytometry
CPT
86430
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to evaluate symptoms like unexplained shortness of breath, chest pain, leg swelling, or stroke risk. It’s also used in diagnosing conditions like deep vein thrombosis (blood clots in veins) or pulmonary embolism (clots in the lungs).

How Is the Test Performed?

A small blood sample is drawn from a vein, usually in your arm. The blood is processed to measure the D-dimer levels using a sensitive lab method. The result helps determine whether you may have a clot-related issue or if further testing is needed.

What Do the Results Mean?

Results are interpreted based on your symptoms and medical history. A higher-than-normal level may indicate an increased risk of clots, while a normal level suggests no significant clot activity. Your doctor will discuss the results with you in the context of your overall health.

Common Conditions Monitored

This test is often used to monitor conditions like venous thromboembolism (blood clots in veins), arterial clots, or after treatments to prevent clots. It can also help guide decisions about anticoagulant medications.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

High-Sensitivity D-Dimer

Frequently asked questions

What Are My Next Steps If My Results Are Abnormal?
If your D-dimer level is elevated, your doctor may recommend additional tests, such as imaging studies (like a CT scan or ultrasound) to confirm a clot or rule out other causes of symptoms. Follow-up may include further blood tests or adjustments to your treatment plan if you’re on clot-preventing medications.
How Often Should I Get This Test?
The frequency depends on your medical condition and treatment plan. Your doctor will determine how often to repeat this test based on your symptoms, risk factors, and response to treatment. Regular monitoring may be needed if you have a history of clotting disorders or are at high risk.
Can I Influence My D-Dimer Levels?
While you can’t directly control D-dimer levels, lifestyle choices like staying active, avoiding smoking, managing weight, and controlling conditions like high blood pressure or diabetes may help reduce your risk of clots. Always follow your doctor’s advice for managing your health.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy