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D-dimer measured by mass concentration via immunoassay (clia)

Published: August 9, 2026Updated: August 16, 2026

This test checks for small protein fragments called D-dimer in your blood. These fragments form when blood clots break down, which can happen after injury or certain medical conditions.

Quick summary

["D-dimer helps identify possible blood clots or conditions that increase clot risk."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
68388-8
Short code
dsDNA IgG Prt IA-aCnc
Synonyms
dsDNA IgG Prt IA-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is D-Dimer Used For?

D-dimer is primarily used to assess whether you might have a blood clot (thrombosis) or deep vein thrombosis (DVT). It can also help rule out conditions like pulmonary embolism, where a clot blocks blood flow in the lungs. Your doctor may order this test if you have symptoms like swelling, pain, or unexplained shortness of breath, or if you’ve had recent surgery or trauma.

How Is the Test Performed?

A small blood sample is drawn from a vein, usually in your arm. The blood is processed to measure D-dimer levels. This test is quick and typically done in a lab setting. No special preparation is usually needed, but your doctor may advise avoiding certain medications or activities for a short time before testing.

What Does a High or Low D-Dimer Level Mean?

A high D-dimer level often suggests an active blood clot or increased risk of clotting, which may require further testing or treatment. A low level usually means there’s little to no clot activity, but it doesn’t rule out all conditions. Your doctor will interpret results in the context of your symptoms and medical history.

When Might You Need This Test?

Your doctor may recommend a D-dimer test if you have symptoms like swelling in your legs, chest pain, or breathing difficulties. It’s also used after surgery, in people with a history of clots, or during pregnancy to monitor for complications. Sometimes, it’s part of a screening process for conditions like cancer or inflammation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: D-Dimer’s Role in Diagnosis and Monitoring

Short name

D-Dimer

Frequently asked questions

Why is D-dimer important in diagnosing blood clots?
D-dimer is a key marker because it’s a direct byproduct of clot breakdown. Elevated levels strongly suggest recent clot formation, helping doctors confirm or rule out conditions like deep vein thrombosis or pulmonary embolism. However, it’s not always definitive on its own, so doctors may combine results with other tests or imaging.
Can D-dimer levels change with certain medications?
Yes, some medications like anticoagulants (blood thinners) or antiplatelet drugs can affect D-dimer levels. If you’re on these medications, your doctor will consider them when interpreting results. Other factors, such as pregnancy, recent surgery, or infections, can also influence D-dimer levels.
Is there any risk or discomfort with this test?
The blood draw itself is minor and usually causes only mild discomfort. There’s a small risk of bruising, swelling, or slight pain at the injection site. Most people don’t experience any serious side effects from this test.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy