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D-dimer, serum/plasma mass concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of D-dimer, a protein fragment produced when blood clots break down. It helps assess the risk of blood clots or conditions like deep vein thrombosis or pulmonary embolism.

Quick summary

["D-dimer helps doctors evaluate clot-related risks and guide treatment decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
33799-8
Short code
dsDNA IgG SerPl IA-aCnc
Synonyms
dsDNA IgG SerPl IA-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is D-Dimer Used For?

D-dimer is primarily used to check for signs of abnormal clot formation. It’s often ordered when you have symptoms like swelling, pain, or breathing difficulties that might suggest blood clots. Doctors may also use it to rule out conditions like deep vein thrombosis (DVT) or pulmonary embolism (PE).

How Is the Test Performed?

A blood sample is taken from a vein, usually in your arm. The blood is then processed to measure the D-dimer levels. The test is quick and typically done in a lab setting. No special preparation is usually needed, but your doctor may advise fasting or avoiding certain medications for some tests.

What Are Common Results and Interpretation?

D-dimer results are not given in absolute numbers but are interpreted in the context of your symptoms and medical history. High levels may suggest recent clot activity, while low levels may indicate no active clotting. Your doctor will discuss the results with you based on your specific situation.

What Might Affect My Results?

Several factors can influence D-dimer levels, including recent surgery, pregnancy, certain medications (like blood thinners), or conditions that increase clot risk. If you’ve had recent trauma, infection, or inflammation, these can also affect results. Always inform your doctor about all medications and health conditions before testing.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

D-Dimer

Frequently asked questions

D-dimer is a key diagnostic tool for conditions involving blood clots. Elevated levels can help confirm a diagnosis of DVT or PE, while very low levels may reduce the likelihood of these conditions. It’s often used alongside other tests, like imaging studies, for a complete evaluation.
D-dimer tests are generally safe and rarely cause side effects. The most common side effect is a mild bruise or soreness at the injection site. If you experience unusual bleeding or signs of infection at the site, contact your healthcare provider immediately.
Yes, D-dimer levels can vary based on your health status and recent activities. For example, if you’ve recently traveled or had a procedure, your levels might be higher. Your doctor will consider these factors when interpreting your results.
No, D-dimer is not a standalone test for diagnosing all blood clot conditions. It’s often used alongside other tests, such as imaging studies (like CT scans or MRIs) or additional blood tests, to get a full picture of your health. Always follow your doctor’s recommendations.
If your D-dimer test result is high, your doctor may recommend further testing or monitoring to check for blood clots. They might also adjust your treatment plan, such as starting blood thinners if needed. Follow-up care will depend on your specific symptoms and medical needs.
If you’re pregnant or planning to become pregnant, D-dimer tests are generally safe. However, discuss any concerns with your healthcare provider, as some blood tests may have different considerations during pregnancy.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy