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Dual-Specific IgG Antibody to Influenza Virus (Hemagglutinin and Neuraminidase)

Published: August 9, 2026Updated: August 16, 2026

This test measures your immune response to past exposure to the influenza virus by detecting specific antibodies against its surface proteins. It helps assess whether your body has developed immunity after infection or vaccination.

Quick summary

["This test helps determine if your immune system has recognized and responded to the flu virus, even if you don’t remember being sick."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58466-4
Short code
dsDNA IgG Titr Ser CLIF
Synonyms
dsDNA IgG Titr Ser CLIF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
8
Ref high
61
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
crithidia-luciliae-if
CPT
82977
SNOMED
3110003
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test looks for antibodies (IgG) that target two key proteins on the influenza virus: hemagglutinin (HA) and neuraminidase (NA). These proteins are critical for the virus’s ability to infect cells. If your body produced these antibodies, it suggests prior exposure, whether from infection or vaccination.

Why It Might Be Ordered

Doctors may order this test if you have symptoms of the flu but test negative for active infection, or if you’re at higher risk for complications (e.g., elderly individuals, those with chronic conditions). It can also help monitor immunity in high-risk groups or after vaccination.

How the Test Works

Blood is drawn and tested using immunoassay methods to detect IgG antibodies against HA and NA. The presence of these antibodies indicates your immune system has likely encountered the virus before, triggering an antibody response.

Sample Collection and Preparation

A small blood sample is taken from your arm. The blood is processed to separate serum (liquid part of blood) for testing. No special preparation is needed, but avoid strenuous activity 24 hours before the test.

Reference range

Adult males: 8-61 U/L; Adult females: 5-36 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Influenza IgG Antibody Panel

Frequently asked questions

What does a positive result mean?
A positive result means your immune system has likely encountered the influenza virus before, producing antibodies against its surface proteins. This could mean you had a past infection or were vaccinated. However, antibodies may not provide long-term protection, so vaccination remains the best way to prevent future flu.
What does a negative result mean?
A negative result means your immune system did not detect these specific antibodies at the time of testing. This could indicate no prior exposure or that your body hasn’t had time to produce antibodies yet. It does not rule out past infection—antibodies may take weeks to develop.
How long does it take to get results?
Results are typically available within 2–5 business days, depending on lab processing times. Follow-up with your healthcare provider if you have questions about your results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy