Skip to content

Anti-dsDNA Antibody, Cerebrospinal Fluid, Qualitative by Chemiluminescent Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test looks for anti-double-stranded DNA antibodies in cerebrospinal fluid (CSF), the fluid that surrounds the brain and spinal cord. It is a specialized test, and its role in routine care is limited.

Quick summary

["Anti-dsDNA in CSF is usually measured as a research or specialized marker, not a standard everyday test."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63234-9
Short code
dsDNA IgM CSF IA-aCnc
Synonyms
dsDNA IgM CSF IA-aCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Is Being Measured

The test detects antibodies that target double-stranded DNA. These antibodies are best known as a marker in lupus (systemic lupus erythematosus), where they are typically measured in blood rather than CSF.

Why CSF Instead of Blood

CSF testing is rarely used for anti-dsDNA. It may be done in specialized settings to study whether such antibodies appear in the fluid around the nervous system, but this is not a routine clinical practice.

How the Test Is Collected

A CSF sample is collected by a healthcare professional, usually through a lumbar puncture (spinal tap). The sample is then tested in the laboratory using an immunoassay with a chemiluminescent (light-based) detection method.

What Results May Mean

Because this is a specialized and non-standard application of anti-dsDNA testing, results should be interpreted by the ordering clinician in the full context of symptoms, other CSF and blood tests, and imaging. A single result does not establish a diagnosis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Anti-dsDNA antibodies are a recognized blood marker associated with lupus nephritis and disease activity in lupus, but their presence in CSF is not a standard diagnostic criterion for any condition. CSF anti-dsDNA testing remains an investigative measurement; clinicians should rely on validated, guideline-supported tests and avoid drawing conclusions from this result alone.

Short name

CSF Anti-dsDNA Ab (Qual)

Frequently asked questions

Is anti-dsDNA in CSF a common test?
No. Anti-dsDNA is most commonly measured in blood. CSF testing is specialized and not part of routine evaluation.
Does a positive result mean I have lupus?
A single CSF anti-dsDNA result cannot diagnose lupus. Diagnosis requires clinical evaluation and appropriate blood and other testing interpreted by your clinician.
How is a CSF sample obtained?
CSF is collected by lumbar puncture (spinal tap), a procedure performed by a trained healthcare professional.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy