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D-dimer mass concentration (serum/plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of D-dimer, a breakdown product of clotted blood that helps assess whether you’ve had a blood clot.

Quick summary

["D-dimer helps identify potential blood clotting risks or recent clot events."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
63235-6
Short code
dsDNA IgM Plr IA-aCnc
Synonyms
dsDNA IgM Plr IA-aCnc
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

What Is D-Dimer?

D-dimer is a protein fragment created when blood clots dissolve naturally. Elevated levels may suggest recent clotting activity, such as deep vein thrombosis (DVT) or pulmonary embolism. Your doctor may order this test to evaluate symptoms like leg swelling, chest pain, or unexplained shortness of breath.

Why Might This Test Be Done?

A healthcare provider may order a D-dimer test if you have symptoms of blood clots (e.g., swelling, pain in legs or chest), a history of clotting disorders, or if you’re being evaluated for conditions like deep vein thrombosis (DVT) or pulmonary embolism. It’s also sometimes used in screening for certain cancers or inflammatory conditions.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is sent to a lab where it’s analyzed for D-dimer levels using a sensitive test that detects the protein fragments. Results are typically available within a few hours.

What Do the Results Mean?

Results are not provided with specific reference ranges, as they depend on clinical context. Very high levels may indicate recent clotting, while very low levels may suggest no active clotting. Your doctor will interpret the result alongside your symptoms, medical history, and other test results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

D-Dimer

Frequently asked questions

What causes elevated D-dimer levels?
Elevated D-dimer levels are most commonly associated with blood clots (thrombosis), such as deep vein thrombosis (DVT) or pulmonary embolism. Other conditions, like pregnancy, severe infections, cancer, or heart failure, may also cause elevated levels, though less commonly. Always discuss symptoms and medical history with your provider.
Can low D-dimer levels indicate anything?
Low D-dimer levels are generally not concerning unless you have a known history of clotting disorders. In some cases, very low levels might suggest conditions like severe liver disease or certain medications that affect blood clotting. Your doctor will consider your overall health and test results.
How often should I get this test?
The frequency of this test depends on your medical needs. Your doctor may recommend it during routine checkups, after a suspected clot event, or if you have a history of clotting risks. Follow-up testing may be needed if initial results are abnormal or if symptoms persist.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy